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td nmr  (Bruker Corporation)


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    Bruker Corporation td nmr
    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined <t>by</t> <t>TD-NMR</t> and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
    Td Nmr, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 94/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/minispec/pmc12953642-363-0-3?v=Bruker+Corporation
    Average 94 stars, based on 29 article reviews
    td nmr - by Bioz Stars, 2026-07
    94/100 stars

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    1) Product Images from "ZFP57 is a regulator of postnatal growth and life-long health"

    Article Title: ZFP57 is a regulator of postnatal growth and life-long health

    Journal: Nature Communications

    doi: 10.1038/s41467-026-68608-9

    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by TD-NMR and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
    Figure Legend Snippet: Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by TD-NMR and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.

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    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined <t>by</t> <t>TD-NMR</t> and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
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    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined <t>by</t> <t>TD-NMR</t> and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
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    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined <t>by</t> <t>TD-NMR</t> and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
    Bruker Minispecs Mq20, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined <t>by</t> <t>TD-NMR</t> and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.
    Minispec Lf50h, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by TD-NMR and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.

    Journal: Nature Communications

    Article Title: ZFP57 is a regulator of postnatal growth and life-long health

    doi: 10.1038/s41467-026-68608-9

    Figure Lengend Snippet: Long-term growth trajectories of male ( A ) and female ( B ) Zfp57 +/-p and Zfp57 m-/+ offspring born to Zfp57 -/- or WT dams, and WT pups cross-fostered to Zfp57 -/- or WT dams. n = 51 for Zfp57 +/-p pups ( n = 27♂, 24♀) from 11 litters, n = 46 for Zfp57 m -/+ pups ( n = 21♂, 25♀)from 12 litters, n = 53 for WT pups CF to WT dam ( n = 26♂, 27♀) from 8 litters, n = 49 for WT pups CF to Zfp57 -/- dam ( n = 24♂, 25♀) from 7 litters. Data are mean ± SEM. C , D Body composition assessment of WT, Zfp57 m-/+ and Zfp57 +/-p male offspring in adulthood, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by TD-NMR and normalised to total body weight. C % Fat mass D Lean/Fat ratio. WT pups: n = 6 raised by WT, 6 CF by WT, 6 CF by Zfp57 -/- . Zfp57 +/-p pups: n = 11 raised by WT, n = 5 CF by WT, n = 8 CF by Zfp57 -/- . Zfp57 m -/+ pups: n = 9 raised by KO, n = 8 CF by WT, n = 7 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Symbols indicate significant comparison types: § Same pups fostered to different maternal genotypes, ∞ Non-cross-fostered pups, € Different pups fostered to WT dam, # Different pups fostered to Zfp57 -/- dam. E Intraperitoneal glucose tolerance test (IP-GTT) of male Zfp57 +/-p offspring (left) and Zfp57 m-/+ offspring (right), raised by or cross-fostered to Zfp57 -/- or WT dams. Zfp57 +/-p offspring born to WT dams is plotted twice for comparison. Zfp57 +/-p pups: n = 8 for pups born to WT, n = 6 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Zfp57 m -/+ pups: n = 8 for pups born to Zfp57 -/- , n = 7 for pups CF to WT, n = 7 for pups CF to Zfp57 -/- . Data are mean ± SEM. F Fat oxidation of male and female WT, Zfp57 m-/+ and Zfp57 +/-p offspring at 6 months of age, raised by their birth mother (plain columns), cross-fostered (CF) by a WT dam (middle white dotted column) or CF by a Zfp57 -/- dam (right pink chequered column), determined by the Promethion high-definition behavioural phenotyping system over 48 h period, dark period is represented by grey background. WT pups: n = 6 raised by WT, 10 CF by WT, 10 CF by Zfp57 -/- ; Zfp57 +/-p pups: n = 23 raised by WT, n = 12 CF by WT, n = 15 CF by Zfp57 -/- ; Zfp57 m -/+ pups: n = 16 raised by KO, n = 15 CF by WT, n = 16 CF by Zfp57 -/- . Exact p values provided as source data. Data are mean ± SEM. One-way ANOVA with Tukey’s corrections. Upset plots below or above the bars represent p value based on colours * p < 0.05, ** p < 0.01, *** p < 0.001. **** p < 0.001. Source data are provided as a file.

    Article Snippet: TD-NMR (LF50H Minispec, Bruker, Coventry, UK) was used to determine longitudinal changes in body composition (lean and fat mass).

    Techniques: Comparison